Overview

Drug Repurposing Encyclopedia (DRE) is a multi-functional drug discovery web server covering four comprehensive drug databases and user-friendly online analytic platforms for drug repurposing over 4,690 consensus drug profiles across 20 organisms.
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DRE comprises drug-pathway association analytic server spanning 20 organisms and three other drug-association functionalities. DRE was built based on the popular Molecular Signatures Database (MSigDB, https://www.gsea-msigdb.org/gsea/msigdb/), the consensus drug profiles from DREIMT (http://www.dreimt.org/), which was based on Connectivity Map (CMap) LINCS gene expression dataset (https://clue.io/). The drug-pathway platform provided 648K organism-specific pathway signatures and 39,7M organism-specific drug-pathway associations after correcting for multiple testing and filtering (FDR < 0.05).
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DRE customized analytic functionalities include drug repurposing, gene set similarity, and gene set enrichment analysis. Drug repurposing analysis allows users to compare their gene signatures with the DRE database and generate a set of drugs that are highly associated with the user-provided gene sets. Gene set similarity analysis allows the user to pass their gene signatures and compare them with the existing signatures in the database to look for pathway signatures with high overlaps with the provided signatures. For gene set enrichment analysis, the user-provided ranked gene sets (i.e., gene symbols and their fold change in two columns) will be used for enrichment analysis with all the pathways present in the database, and all pathways with multiple corrections done will be provided to the user (filtering based on provided the user will do FDR).